A 43 old male patient  resident of nalgonda ,farmer by occupation ,presented to casualty with complaints of :
Low grade Fever since 1 year  .
Cough with sputum since 1 year 
 Complaints of neck pain since 6 months
 Weakness of  all both lower limbs since 6 months .
HOPI :
Patient was married at age of 25 and have 3 children , one son and two daughters . He is farmer by occupation . He is occasional alcoholic and chronic smoker (1-2 packs/day) since 20 years . He was apparently alright till 33 years of age , then in view of generalised weakness pt went for routine evaluation and got diagnosed with diabetes mellites- type 2 and is using OHA since 10 years . He takes his medication regularly .
Patient  had history of fever since 1 year which was low grade not associated with chills and rigors, intermittent, associated with diurnal variation and  night sweats.
He also complains of cough with scanty white color ,mucoid expectorant since 1 year, non foul smelling, non blood tinged . No diurnal variation of cough and no chest pain .
He went to local rmp and got symptomatic treatment .
He later developed neck pain , which was sudden in onset gradually progressive . No history of trauma .No radiation .
He then developed weakness of both lower limbs  which was insidious in onset ,gradually progressive in nature over 6 months . He had difficulty in standing and walking  .No history of upper limb weakness .

H/o difficulty in standing from sitting position present.
H/o difficulty in climbing stairs present .
H/o slippage of chappal while walking without knowledge
H/o difficulty in sqatting  present .

No h/o difficulty in getting up from lying down.
no h/o difficulty in holding pen/buttoning/unbuttoning
no h/o difficulty in breathing 
no h/o difficulty in lifting the head off the pillow
no h/o difficulty to roll over the bed
no h/o involuntary movements.
no h/o fasciculations/muscle twitchings .

 h/o sensory deficit in feeling clothes present.
H/o loss of  hot/cold sensations present .
H/o tingling and numbness in UL & LL present .
H/O band like sensation present .
H/o cotton wool sensations present .

no h/o low backache
no h/o trauma 
no h/o giddiness while washing face
no h/o urgency/hesitancy/increased frequency of urine
no h/o urinary incontinence
h/o fever/
No h/o nausea/ vomiting/diarrhea
no h/o seizures
no h/o spine disturbances
no h/o head trauma
no h/o loss of memory
no h/o abnormality in perception of smell
no h/o blurring of vision
no h/o double vision/difficulty in eye movements
no h/o abnormal sensation of face
no h/o difficulty in chewing food
no h/o difficulty in closing eyes
no h/o drooling of saliva
no h/o giddiness/swaying
no h/o difficulty in swallowing
no h/o dysphagia/dysphasia
no h/o tongue deviation
no h/o difficulty in reaching objects
no h/o tremors/tongue fasciculations
no h/o incoordination or difficulty in performing task
no h/o fever/neck stiffness
no h/o loss of consciousness and involuntary movements , no h/o irrelevant talk ,no slurring of speech ,no h/o memory loss and hallucinations .no sleep disturbances .

Past history:

No h/o similar complaints in past.

K/C/O DM-2 since 10 years on Glimi -m1 tablet .
Not a known case of HTN/EPILEPSY/CVA/CAD/TB

FAMILY HISTORY - NOT SIGNIFICANT.

SURGICAL HISOTRY - No previous surgeries or blood transfusions.


Personal history:

Mixed diet with normal appetite and normal bowel/bladder movements
H/o alcohol consumotion since 90ml weekly twice since 20 years.
H/o smoking  (1-2 pacs per day ) since 20 years .

Summary
Insidious , progressive bilateral lower limb weakness with loss of fine touch and temperature and paresthesia.

General Examination:


He is a thin built man, who was conscious, coherent
PR of 80bpm ,regular ,normovolemic .
Bp - 110/80mmhg
Temp - 98.3 F
SpO2 - 99%
RR - 20 cpm
GRBS - 120 mg/dl.

Head to toe examination:


Hair - Black, thick, non easily pluckable. No lesions over the scalp.
Eyes - No pallor, no icterus.
General head & neck examination - No abnormalities. No lymphadenopathy.
Axial- Tenderness over cervical spine +
Fingers & Nails - Clubbing +
Lower limbs - No pedal edema .

No neuro -cutaneous markers noted .


CNS EXAMINATION : 

HMF-
 Patient conscious ,co -operative ,coherent . 
Oriented to place/time/person
no h/o  aphsia/dysarthria
no h/o dysphonia
Recent and remote memory intact .
no h/o emotional lability .

MMSE- 30 .

1.      CRANIAL NERVES

CRANIAL NERVE

TEST

RIGHT

LEFT

I

Sense of smell

i)                    Coffee

ii)                  Asafoetida

 

+

+

 

+

+

II

i) Visual acuity – Snellens Chart

ii) Field of vision – Confrontation test

iii) Colour vision – Ishihara chart

iv) Fundus

6/6

Normal

Normal

Normal

6/6

Normal

Normal

Normal

III, IV, VI

i)                    Extra-ocular movements

ii)                  Pupil – Size

iii)                Direct Light Reflex

iv)                Consensual Light Reflex

v)                  Accommodation Reflex

vi)                 Ptosis

vii)      Nystagmus

viii)    Horners syndrome

full

4mm

Present

Present

Present

Absent

Absent

No

full

4mm

Present

Present

 Present

Absent

Absent

No

V

i) Sensory -over face and buccal mucosa

ii) Motor – masseter, temporalis, pterygoids

iii) Reflex

a.       Corneal Reflex

b.      Conjunctival Reflex

c.       Jaw jerk

Normal

Normal

 

Present

Present

Present

Normal

Normal

 

Present

Present

Present


VII

i) Motor –

nasolabial fold

hyeracusis

occipitofrontalis

orbicularis oculi

orbicularis oris

buccinator

platysma

ii) Sensory –

Taste of anterior 2/3rds of tongue(salt/sweet)

Sensation over tragus

iii) Reflex –

Corneal

Conjunctival

iv) Secretomotor –

Moistness of the eyes/tongue and buccal mucosa

 

Present

Absent

Good

Good

Good

Good

Good

 

Normal

 

Normal

 

Present

Present

 

Normal

 

Present

Absent

Good

Good

Good

Good

Good

 

Normal

 

Normal

 

Present

Present

 

Normal

VIII

i) Rinnes Test

ii) Webers Test

 

 

iii) Nystagmus

Positive

Not lateralised

 

Absent

Positive

 

 

 

Absent

IX, X

i) Uvula, Palatal arches, and movements

 

 

 

ii) Gag reflex

iii) Palatal reflex

Centrally placed and symmetrical

 

Present

Present

 

 

 

 

Present

Present

X1

i) trapezius

ii) sternocleidomastoid

Good

Good

Good

Good

XII

i) Tone

ii) Wasting

iii) Fibrillation

iv) Tongue Protrusion to the midline and either side

Normal

No

No

Normal

Normal

No

No

Normal





MOTOR SYSTEM :
                                              Right.         Left
Bulk:    inspection       normal.     Normal
             palpation.       Normal.     Normal
Measurements       U/l      28cm.  28cm
                               L/L    37cm.         37 cm


Tone:               UL         hypertonia     hypertonia
                         LL.         hypertonia.      hypertonia
Power              UL.                4/5.              4/5
             LL:      

  iliopsoas                3/5.              3/5 
   adductor femoris            3/5.               3/5
       gluteus medius             3/5.               3/5
   gluteus maximus            3/5.               3/5
              hamstrings            3/5.               3/5
quadriceps femoris            3/5.               3/5
tibialis anterior.                   3/5.               3/5
tibialis posterior.                 3/5.               3/5
peroneii.                                3/5.               3/5
gastronemius.                     3/5.               3/5
extensor -
         digitorum longus.       2/5.               2/5
flexor digitorum longus      2/5.               2/5

Reflexes.  
   Superficial reflexes
                       Right.           Left
Corneal.            P                  P
Conjunctival    P.                  P
Abdominal.      +               +
Plantar            EXTENSOR         EXTENSOR
cremasteric.    +                +


    Deep tendon reflexes 
                     Right.             Left
Biceps.          +3                  +3
Triceps.         +3                ++3
Supinator.     +3                 ++3
Knee              +3                   +3
Ankle.            +3                  +3

 Clonus - both knee and ankle absent.
 
SENSORY SYSTEM 
                                    RIGHT.           LEFT
SPINOTHALAMIC 
             crude touch.   N.                   N
                 pain.     UL-      N                N
                              LL-     -                 -

            temperature.   -                -
post:
             fine touch.     -                -
             vibration.       -                 -
     position sensor.    -                  -

 cortical 
 2 point discrimination -                 -
tactile localisation.     -               -

CEREBELLUM
titubation - absent
ataxia - absent
hypertonia.                present            present


Respiratory system examination : 
Inspection
Rt supraclavicular hollowness
Movements of chest appears to be reduced on right side in supraclavicular region
Palpation vocal fremitus decreased in rt supraclavicular area 
Percussion
 Dull note in rt supraclavicular and suprascapular region
Auscultation 
Wheeze in bilateral lung fields on presentation 
Crepitations in left infra axillary area and left infrascapular area .

CARDIO VASCULAR SYSTEM : S1S2 heard.
No murmurs. No palpable heart sounds.

PER ABDOMEN - 
SOFT , NO ORGANOMEGALY.
NO GUARDING AND RIGIDITY.
BOWEL SOUNDS PRESENT .

INVESTIGATIONS :

Hemoglobin  - 12g/dl
TLC - 10,600 cells/cumm
Platelets - 2.90 Lakhs/cumm
Peripheral smear - Normocytic Normochromic blood picture

ESR - 60mm in 1st hour

HBsAg, HIV, HCV - Negative

RBS - 112 mg/dl


Blood Urea - 43 mg/dl
Serum creatinine - 1 mg/dl
Serum Potassium - 4.1 mg/dl
Serum Sodium - 138 mg/dl
Serum Chloride - 100 mg/dl

Complete Urine Examination - No abnormalities 

Sputum for Culture & Sensitivity:
Gram stain, Direct smear: Plenty of inflammatory cells ( more than 20/hpf). Few epithelial cells, 1-2/hpf.
Plenty of gram positive cocci in pairs in short chains seen.
Impression- Normal flora grown.




FINAL DIAGNOSIS : 

CHRONIC BILATERAL SYMMETRICAL MOTOR SENSORY WEAKNESS BOTH  PROXIMAL AND DISTAL MUSCLE  WEAKNESS .
K/c/o - DM -2 .

QUADRIPARESIS SECONDARY TO COMPRESSIVE MYELOPATHY .( HIGH CORD LEISON - C3-C4).








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